Purpose:
@EN To evaluate the effect of increased mineral intake by high mineral fortified preterm formula on bone mineralization, rickets of prematurity, and biochemical altrations in very low birth weight infants during the first two months of life.
@ES Methods:
@EN 42 very low birth weight infants, who were born at Severance Hospital during the 2 years from July, 1994 through June, 1996, were randomly assigned to either hi-mineral group (n=20) or control group (n=22). Hi-mineral group has received high
mineral
fortified preterm formula which has double the amount of Ca and P/100Kcal compared with standard preterm formula (Control group). Both groups have started assigned formula from the initial feeding and continued until 2.3 kg or discharge. Total
body
bone
mineral content was measured by Dual energy x-ray absorptiometery (0Lunar, WI) at 4 and 8 wks of age. Wrist and Kness Radiographs were obtained at 2 wks interval till 2 months of age and thereafter monthly. Serum minerals and alkaline phosphatase
concentrations were measured weeklv, and serum 25-hydroxyvitamin D, 1,25-dihydroxyvitamin D, PTH and osteocalcin (a marker of bone turnover) at 1 month of age.
@ES Results:
@EN Hi-mineral group and control group were similar in gestational age and birth weight. By design, enteral Ca and P intakes were higher in hi-mineral group showed higher bone mineral accretion than control. Occurrence of radiologic rickets were
similar
between groups. Serum minerals and alkaline phosphatase were not different between groups, and maintained within the normal range in both groups. Serum 25-hydroxyvitamin D, 1,25-dihydroxyvitamin D. PTH and osteocalcin concentrations were not
different
between groups.
@ES Conclusions:
@EN High mineral fortified preterm formula would be beneficial for enteral nutrition of VLBW infants during early life in maintaining adequate bone mineralization and calcium homeostasis. More aggressive nutritional support may be needed to
prevent
the
development of rickets and bone demineralization in VLBW infants during early life.
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